There's a popular medical thriller novel in which a global pandemic is intentionally set off by an evil plot designed to reduce the human population. In the book, a nefarious drug company inserts live avian flu viruses into vaccine materials that are distributed to countries around the world to be injected into patients as "flu shots." Those patients then become carriers for these highly-virulent strains of avian flu which go on to infect the world population and cause widespread death.
There's only one problem with this story: It's not fiction. Or, at least, the part about live avian flu viruses being inserted into vaccine materials isn't fiction. It's happening right now.
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